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◆ Selected Publications ◆

  1. 1.Wen M, Guo X, Sun P, Xiao L, Li J, Xiong Y, Bao J, Xue T, Zhang L, Tian C (2015) Site-specific fluorescence spectrum detection and characterization of hASIC1a channels upon toxin mambalgin-1 binding in live mammalian cells.ChemCommun (Camb)51(38):8153-6.

    2.Hu QX, Dong JH, Du HB, Zhang DL, Ren HZ, Ma ML, Cai Y, Zhao TC, Yin XL, Yu X,Xue T, Xu ZG, Sun JP(2014) Constitutive Gαi Coupling Activity of VLGR1 and its Regulation by PDZD7. J BiolChem 289(35):24215-2

    3.Zhong X, Gutierrez C, Xue T, Hampton C, Vergara MN, Park T, Zambidis E, Meyer J, Gamm MD, YauKW, Canto-Soler MV (2014). Human-iPSC-Derived, 3-Dimensional Retinal Cups with Functional Photoreceptors. Nature Communications5:4047.

    4.Welsbie DS, Yang Z, Ge Y, Mitchell KL, Zhou X, Martin SE, Berlinicke CA, Hackler L Jr, Fuller J, Fu J, Cao LH, Han B, Auld D, Xue T, Hirai SI, Germain L, Simard-Bisson C, Blouin R, Nguyen JV, Davis CH, Enke RA, Boye SL, Merbs SL, Marsh-Armstrong N, Hauswirth WW, Diantonio A, Nickells RW, Inglese J, Hanes J, Yau KW, Quigley HA, Zack DJ. (2013). Functional genomic screening identifies dual leucine zipper kinase as a key mediator of retinal ganglion cell death.Proc Natl AcadSci USA. 110(10):4045-50.

    5.Pearson RA, Barber AC, Rizzi M, Hippert C, Xue T, West EL, Duran Y, Smith AJ, Chuang JZ, Azam SA, Luhmann UFO, Benucci A, Sung CH, Carandini M, Yau KW, Sowden JC, Ali RR. (2012). Restoration of vision after transplantation of photoreceptors. Nature. 485(7396):99-103.

    6.Xue T?, Do MT, Riccio A, Jiang Z, Hsieh J, Wang HC, Merbs SL, Welsbie DS, Yoshioka T, Weissgerber P, Stolz S, Flockerzi V, Freichel M, Simon MI, Clapham DE, Yau KW?. (2011). Melanopsin Signaling in Mammalian Iris and Retina. Nature. 479(7371):67-73. (Research Article) (? co-corresponding authors); Faculty of 1000:

    7.Do MT, Kang SH, Xue T, Zhong H, Liao HW, Bergles DE, Yau KW. (2009) Photon capture and signalling by melanopsin retinal ganglion cells. Nature. 457(7227):281-7. (Research Article); Faculty of 1000:

    8.Luo DG, Xue T, Yau KW. (2008) How vision begins: An odyssey. Proc Natl AcadSci U S A.105(29):9855-62 (review)

    9.Fu YB*, Kefalov V*, Luo DG*, Xue T*, Yau KW. (2008) Quantal noise from human red cone pigment. Nature Neuroscience. 11(5):565-71(* equal contributions)

    10. Xue T, Siu CW, Lieu DK, Lau CP, Tse HF, Li RA. (2007) Mechanistic role of I(f) revealed by induction of ventricular automaticity by somatic gene transfer of gating-engineered pacemaker (HCN) channels. Circulation. 115(14):1839-1850.

    11. El-Kholy W, MacDonald PE, Fox JM, Bhattacharjee A, Xue T, Gao X, Zhang Y, Stieber J, Li RA, Tsushima RG, Wheeler MB. (2007) Hyperpolarization-activated cyclic nucleotide-gated channels in pancreatic beta-cells. MolEndocrinol. 21(3):753-764.

    12.Tse HF, Xue T, Lau CP, Siu CW, Wang K, Zhang QY, Tomaselli GF, Akar FG, Li RA (2006). A bio-artificial sinus node constructed via in vivo gene transfer of an engineered pacemaker (HCN) channel reduces the dependence on electronic pacemaker in a sick sinus syndrome model. Circulation114: 1000-1011. Issue highlights, GROUND-BREAKING STUDY OF 2007 AHA.

    13.Ardehali H, Xue T, Dong P, Machamer C (2005). Targeting of the mitochondrial membrane proteins to the cell surface for functional studies.BiochemBioph Res Comm.338(2):1143-51.

    14.Abraham MR, Henrikson CA, Tung L, Chang MG, Aon M, Xue T, Li RA, O'Rourke B, Marban E (2005). Antiarrhythmic engineering of skeletal myoblasts for cardiac transplantation. Circ Res. 97:159-67.

    15.Moore JC, van Laake LW, Braam SR, Xue T, Tsang SY, Ward D, Passier R, Tertoolen LL, Li RA, Mummery CL (2005). Human embryonic stem cells: Genetic manipulation on the way to cardiac cell therapies. ReprodToxicol.20:377-91.

    16.Azene EM, Xue T, Marban E, Tomaselli GF, Li RA (2005). Non-equilibrium behavior of HCN channels: Insights into the role of HCN channels in native and engineered pacemakers. Cardiovasc Res. 67:263-73.

    17.Wang G*, Xue T*, Tsang SY, Wong J, Cheng L, Zhang J, Li GR, Lau CP, Li RA, Tse HF(2005).Electrophysiological properties of pluripotent human and mouse embryonic stem cells. Stem Cells. 23(10):1526-34. (* equal contributions)

    18.Xue T*, Cho H*, Akar F*, Tsang SY, Jones S, Marbán E, Tomaselli GF, Li RA (2005). Functional Integration of Electrically Active Cardiac Derivatives from Genetically Engineered Human Embryonic Stem Cells with Quiescent Recipient Ventricular Cardiomyocytes. Insights into the Development of Cell-Based Pacemakers. Circulation. 111:11-20.issue highlights, (Best Paper Award, Circulation. 2005) (* equal contribution)

    19. Xue T, Sato K, Kodama K, Ennis I, French RJ,Li RA (2003).Novel interactions identified between ?-conotoxinand the Na+ channel Domain I P-loop: Implications for toxin-pore binding geometry. Biophys. J.85(4):2299-310.

    20.Azene EM*,Xue T*, Li RA (2003). Molecular basis of the effects of potassium on heterologously-expressed pacemaker (HCN) channels. J. Physiol. (London) 547(2):349-356. (* equal contributions)

    21.HenriksonCA, Xue T, Dong P, Sang D, Marbán E, Li RA (2003). Identification of a surface charged residue in the S3-S4 linker of pacemaker (HCN) channel that influences activation gating. J. Biol. Chem. 278(16):13647-54.

    22.  Li RA, Ennis I, Xue T, Nguyen HM, Tomaselli GF, Goldin AL,Marbán E (2003).Molecular basis of isoform-specific ?-conotoxin block of cardiac, skeletal muscle and brain Na channels.J. Biol. Chem. 278(10):8717-24.

    23.Xue T, Li RA (2002). An external determinant in the S5-P linker of the pacemaker (HCN) channel identified by sulfhydryl modification.  J. Biol. Chem. 277(48):46233-42.

    24.Xue T, Marbán E, Li RA (2002). Dominant-negative suppression of HCN1- and HCN2-encoded pacemaker currents by an engineered HCN1 construct: Insights into structure-function relationships and multimerization. Circ. Res.90:1267-1273.

    25.Li RA, Sato K, Kodama K, Kohno T, Xue T, Tomaselli GF, Marban E. (2002). Charge conversion enables quantification of the proximity between a normally-neutral mu-conotoxin (GIIIA) site and the Na+ channel pore. FEBS Lett. 511(1-3):159-164.