2020

1. Kai An †, Huan Zhao †*, Ying Miao, Qi Xu, Yu-Fei. Li, Yu-Qian Ma, Yi-Ming Shi, Jia-Wei Shen, Jian-Jun Meng, Yong-Gang Yao, Zhi Zhang, Ju-Tao Chen, Jin Bao, Mei Zhang, and Tian Xue*, A Circadian Rhythm-gated Subcortical Pathway for Nighttime Light Induced Depressive-like Behaviors in Mice. Nature Neuroscience, 2020, in press(† equal contributions, *co-corresponding authors)

   
   

2. Lu, Y#, Shiau, F#, Yi, W#, Lu, S, Wu, Q, Pearson, J.D, Kallman, A, Zhong, S, Hoang, T, Zuo, Z, Fangqi Zhao, Mei Zhang, Nicole Tsa,Yan Zhuo, Sheng He, Jun Zhang, Genevieve L. Stein-O’Brien, Thomas D. Sherman, Xin Duan, Elana J. Fertig, Loyal A. Goff, Donald J. Zack, James T. Handa, Tian Xue*, Rod Bremner*, Seth Blackshaw*, Xiaoqun Wang*, Brian S. Clark* (2020). Single-Cell Analysis of Human Retina Identifies Evolutionarily Conserved and Species-Specific Mechanisms Controlling Development. Developmental Cell. https://doi.org/10.1016/j.devcel.2020.04.009. (*co-corresponding authorst)

   
   

3. Xie H#, Zhang W#, Zhang M#*, Akhtar T, Li Y, Yi W, Sun X, Zuo Z, Wei M, Fang X, Yao Z, Dong K, Zhong S, Liu Q, Shen Y, Wu Q, Wang X, Zhao H, Bao J, Qu K*, Xue T*†, Chromatin accessibility analysis reveals regulatory dynamics of developing human retina and hiPSCderived retinal organoids. Sci. Adv. 6, eaay5247 (2020). (*co-corresponding authors，†lead contact)

   
   

   2019

4. Akhtar T, Xie H, Khan MI, Zhang M*, Xue T*† (2019). Accelerated photoreceptor differentiation of hiPSC-derived retinal organoids by contact co-culture with retinal pigment epithelium, Stem Cell Research, https://doi.org/10.1016/j.scr.2019.101491. (*co-corresponding authors，†lead contact)

   
   

5. Ma Y#, Bao J#*, Zhang Y#, Li Z, Zhou Z, Zhou X, Wan C, Huang L, Zhao Y, Han G*, XueT*† (2019). Mammalian Near-Infrared Image Vision through Injectable and Self-Powered Retinal Nanoantennae. Cell 177(2): 243-255 e215. (*co-corresponding authors，†lead contact)

   
   

6. Cai Y#, Cheng T#, Yao Y#, Li X, Ma Y, Li L, Zhao H, Bao J, Zhang M*, Qiu Z*, Xue T*†(2019). In vivo genome editing rescues photoreceptor degeneration via a Cas9/RecA-mediated homology-directed repair pathway. Sci Adv 5(4): eaav3335. (*co-corresponding authors，†lead contact)

   
   

7. Yu N, Huang L, Zhou Y*, Xue T*, Chen Z*, and Han G* (2019). Near-Infrared-Light Activatable Nanoparticles for Deep-Tissue-Penetrating Wireless Optogenetics.Adv Healthc Mater, e1801132. (*co-corresponding authors)(review)

   
   

   2018

8. Zhu H#, Wang N#, Yao L, Chen Q, Zhang R, Qian J, Hou Y, Guo W, Fan S, Liu S, Zhao Q, Du F, Zuo X, Guo Y, Xu Y, Li J, Xue T, Zhong K, Song X, Huang G*, Xiong W* (2018). Moderate UV exposure enhances learning and memory by promoting a novel glutamate biosynthetic pathway in the brain. Cell. 173, 1716-1727 e1717.

   
   

9. Ye F, Huang Y, Li J, Ma Y, Xie C, Liu Z, Deng X, Wan J, Xue T, Liu W, Zhang M (2018). An unexpected INAD PDZ tandem-mediated plcbeta binding in Drosophila photo receptors. Elife.7:e41848.

   
   

10. Deng K, Shen J, Wang W, Li M, Li H, Chen C, Zhao H, Zhang M, Xue T, Liu Q, Lui VWY, Hong B*, Lin W* (2018). Sodium chloride (NaCl) potentiates digoxin-induced anti-tumor activity in small cell lung cancer. Cancer Biol Ther. Sep 5:1-13.

    
    

11. Deng WL, Gao ML, Lei XL, Lv JN, Zhao H, He KW, Xia XX, Li LY, Chen YC, Li YP, Pan D, Xue T, Jin, Z. B (2018). Gene Correction Reverses Ciliopathy and Photoreceptor Loss in iPSC-Derived Retinal Organoids from Retinitis Pigmentosa Patients. Stem Cell Reports,10(4):1267-1281.

    
    

12. Tang J, Qin N, Chong Y, Diao Y, Yiliguma, Wang Z, Xue T, Jiang M, Zhang J*, Zheng G* (2018). Nanowire arrays restore vision in blind mice. Nature Communications,9(1):786.

    
    

13. Cheng J, Huang X, Liang Y, Xue T, Wang L*, Bao J* (2018). Plasticity of Light-induced Concurrent Glutamatergic and GABAergic Quantal Events in the Suprachiasmatic Nucleus. J Biol Rhythms, 33(1):65-75.

    
    

    2017

14. Li Q, Cui M, Yang F, Li N, Jiang B, Yu Z, Zhang D, Wang Y, Zhu X, Hu H, Li PS, Ning SL, Wang S, Qi H, Song H, He D, Lin A, Zhang J, Liu F, Zhao J, Gao L, Yi F, Xue T, Sun JP, Gong Y, Yu X(2017). A cullin 4B-RING E3 ligase complex fine-tunes pancreatic δ cell paracrine interactions. J Clin Invest. 127(7):2631-2646.

    
    

15. Wang Q, Yue WWS, Jiang Z, Xue T, Kang SH, Bergles DE, Mikoshiba K, Offermanns S, Yau KW (2017). Synergistic Signaling by Light and Acetylcholine in Mouse Iris Sphincter Muscle. Curr Biol. 27(12):1791-1800.
    

    
    

16. Zhao H, Ma YQ, An K, Hu JX, Cai Y, Bao J, Xue T. (2017) Phototransduction and brain circuitry of non-image-forming vision.  Sci Sin Vitae, 2017, 47: 69–77.(review)
    

    
    

17. Liu CH, Gong Z, Liang ZL, Liu ZX, Yang F, Sun YJ, Ma ML, Wang YJ, Ji CR, Wang YH, Wang MJ, Cui FA, Lin A, Zheng WS, He DF, Qu C, Xiao P, Liu CY, Thomsen ARB, Joseph Cahill T, Kahsai AW, Yi F, Xiao KH, Xue T, Zhou Z, Yu X, Sun JP (2017). Arrestin-biased AT1R agonism induces acute catecholamine secretion through TRPC3 coupling. Nat Communications 8:14335.
    

    
    

    2015

18. Wen M, Guo X, Sun P, Xiao L, Li J, Xiong Y, Bao J, Xue T, Zhang L, Tian C (2015). Site-specific fluorescence spectrum detection and characterization of hASIC1a channels upon toxin mambalgin-1 binding in live mammalian cells. Chem Commun (Camb)51(38):8153-6.
    

    
    

    2014

19. Hu QX, Dong JH, Du HB, Zhang DL, Ren HZ, Ma ML, Cai Y, Zhao TC, Yin XL, Yu X, Xue T, Xu ZG, Sun JP (2014). Constitutive Gαi Coupling Activity of VLGR1 and its Regulation by PDZD7. J Biol Chem289(35):24215-2
    

    
    

20. Zhong X, Gutierrez C, Xue T, Hampton C, Vergara MN, Park T, Zambidis E, Meyer J, Gamm MD, Yau KW, Canto-Soler MV (2014). Generation of three dimensional retinal tissue with functional photoreceptors from human iPSCs. Nature Communications5:4047.
    

    
    

    2002-2013

21. Welsbie DS, Yang Z, Ge Y, Mitchell KL, Zhou X, Martin SE, Berlinicke CA, Hackler L Jr, Fuller J, Fu J, Cao LH, Han B, Auld D, Xue T, Hirai SI, Germain L, Simard-Bisson C, Blouin R, Nguyen JV, Davis CH, Enke RA, Boye SL, Merbs SL, Marsh-Armstrong N, Hauswirth WW, Diantonio A, Nickells RW, Inglese J, Hanes J, Yau KW, Quigley HA, Zack DJ (2013). Functional genomic screening identifies dual leucine zipper kinase as a key mediator of retinal ganglion cell death. Proc Natl Acad Sci U S A. 110(10):4045-50.
    

    
    

22. Pearson RA, Barber AC, Rizzi M, Hippert C, Xue T, West EL, Duran Y, Smith AJ, Chuang JZ, Azam SA, Luhmann UFO, Benucci A, Sung CH, Carandini M, Yau KW, Sowden JC, Ali RR (2012). Restoration of vision after transplantation of photoreceptors. Nature. 485(7396):99-103.
    

    
    

23. Xue T*, Do MT, Riccio A, Jiang Z, Hsieh J, Wang HC, Merbs SL, Welsbie DS, Yoshioka T, Weissgerber P, Stolz S, Flockerzi V, Freichel M, Simon MI, Clapham DE, Yau KW*. (2011). Melanopsin Signaling in Mammalian Iris and Retina. Nature. 479(7371):67-73. (*co-corresponding authors; Faculty of 1000:f1000.com/13360986).
    

    
    

24. Do MT, Kang SH, Xue T, Zhong H, Liao HW, Bergles DE, Yau KW. (2009) Photon capture and signalling by melanopsin retinal ganglion cells. Nature.457(7227):281-7. (Faculty of 1000:f1000.com/1144855).
    

    
    

25. Luo DG, Xue T, Yau KW. (2008) How vision begins: An odyssey. Proc Natl Acad Sci U S A.105(29): 9855-62. (review)
    

    
    

26. Fu YB#, Kefalov V#, Luo DG#, Xue T#, Yau KW (2008). Quantal noise from human red cone pigment. Nature Neuroscience. 11(5):565-71.  (#equal contributions)
    

    
    

27. Xue T, Siu CW, Lieu DK, Lau CP, Tse HF, Li RA (2007). Mechanistic role of I(f) revealed by induction of ventricular automaticity by somatic gene transfer of gating-engineered pacemaker (HCN) channels. Circulation. 115(14):1839-1850.
    

    
    

28. El-Kholy W, MacDonald PE, Fox JM, Bhattacharjee A, Xue T, Gao X, Zhang Y, Stieber J, Li RA, Tsushima RG, Wheeler MB. (2007) Hyperpolarization-activated cyclic nucleotide-gated channels in pancreatic beta-cells. Mol Endocrinol.21(3):753-764.
    

    
    

29. Tse HF, Xue T, Lau CP, Siu CW, Wang K, Zhang QY, Tomaselli GF, Akar FG, Li RA (2006).A bio-artificial sinus node constructed via in vivo gene transfer of an engineered pacemaker (HCN) channel reduces the dependence on electronic pacemaker in a sick sinus syndrome model.Circulation114: 1000-1011. Issue highlights, GROUND-BREAKING STUDY OF 2007 AHA.
    

    
    

30. Ardehali H, Xue T, Dong P, Machamer C (2005).Targeting of the mitochondrial membrane proteins to the cell surface for functional studies.Biochem Bioph Res Comm. 338(2):1143-51.
    

    
    

31. Abraham MR, Henrikson CA, Tung L, Chang MG, Aon M, Xue T, Li RA, O'Rourke B, Marban E (2005).Antiarrhythmic engineering of skeletal myoblasts for cardiac transplantation.Circ Res. 97:159-67.
    

    
    

32. Moore JC, van Laake LW, Braam SR, Xue T, Tsang SY, Ward D, Passier R, Tertoolen LL, Li RA, Mummery CL (2005). Human embryonic stem cells: Genetic manipulation on the way to cardiac cell therapies. Reprod Toxicol. 20:377-91.
    

    
    

33. Azene EM, Xue T, Marban E, Tomaselli GF, Li RA (2005).Non-equilibrium behavior of HCN channels: Insights into the role of HCN channels in native and engineered pacemakers.Cardiovasc Res. 67:263-73.
    

    
    

34. Wang G#, Xue T#, Tsang SY, Wong J, Cheng L, Zhang J, Li GR, Lau CP, Li RA, Tse HF (2005).Electrophysiological properties of pluripotent human and mouse embryonic stem cells.Stem Cells. 23(10):1526-34. (#equal contributions)
    

    
    

35. Xue T#, Cho H#, Akar F#, Tsang SY, Jones S, Marbán E, Tomaselli GF, Li RA (2005).Functional Integration of Electrically Active Cardiac Derivatives from Genetically Engineered Human Embryonic Stem Cells with Quiescent Recipient Ventricular Cardiomyocytes. Insights into the Development of Cell-Based Pacemakers. Circulation. 111:11-20. issue highlights. (Best Paper Award, Circulation. 2005) (#equal contribution)
    

    
    

36. Xue T, Sato K, Kodama K, Ennis I, French RJ, Li RA (2003).Novel interactions identified between µ-conotoxin and the Na+ channel Domain I P-loop: Implications for toxin-pore binding geometry. Biophys. J.85(4):2299-310.
    

    
    

37. Azene EM#, Xue T#, Li RA (2003).Molecular basis of the effects of potassium on heterologously-expressed pacemaker (HCN) channels.J. Physiol. (London) 547(2):349-356. (#equal contributions )
    

    
    

38. Henrikson CA, Xue T, Dong P, Sang D, Marbán E, Li RA (2003).Identification of a surface charged residue in the S3-S4 linker of pacemaker (HCN) channel that influences activation gating.J. Biol. Chem. 278(16):13647-54.
    

    
    

39. Li RA, Ennis I, Xue T, Nguyen HM, Tomaselli GF, Goldin AL, Marbán E (2003).Molecular basis of isoform-specific µ-conotoxin block of cardiac, skeletal muscle and brain Na channels. J. Biol. Chem. 278(10):8717-24.
    

    
    

40. Xue T, Li RA (2002). An external determinant in the S5-P linker of the pacemaker (HCN) channel identified by sulfhydryl modification. J. Biol. Chem.277(48):46233-42.
    

    
    

41. Xue T, Marbán E, Li RA (2002). Dominant-negative suppression of HCN1- and HCN2-encoded pacemaker currents by an engineered HCN1 construct: Insights into structure-function relationships and multimerization.Circ. Res.90:1267-1273.
    

    
    

42. Li RA, Sato K, Kodama K, Kohno T, Xue T, Tomaselli GF, Marban E. (2002). Charge conversion enables quantification of the proximity between a normally-neutral mu-conotoxin (GIIIA) site and the Na+ channel pore. FEBS Lett.511(1-3):159-164.